Our Thesis on Chronic Care Management

Last updated June 2025.

At 2048 Ventures, we are obsessed with the future and invest in the earliest-stage companies that establish defensibility through data and technology.

Chronic conditions continue to account for the most significant healthcare costs in the United States. We are excited about opportunities for chronic care management solutions to manage disease symptoms and improve quality of life.

We believe that the next era of chronic care will include:

• A patient experience with protocols and recommendations, custom tailored to the condition and the individual.
• Qualitative and quantitative data on patient biomarkers, lifestyle, and environmental inputs, with devices as a core offering. We love low cost measurement devices and the ability to sense and respond effortlessly.
• Teams of medical professionals for diagnosis and management of the care journey.

Chronic Care Startups We Want to Meet

We want to meet founders who are hyper-focused on building a world-class, personalized patient experience. The winning teams, in our opinion, will have deep expertise in the condition space and a technical founder on the team. They will have exceptional focus on the ICP: their needs, their habits, what is missing from their current care experience, and information that has the potential to make their lives better.

We are looking to fund companies:

• Providing care to patients with the following chronic conditions: autoimmune diseases, headache, hormone diseases, neurodegeneration, and kidney diseases. These conditions not only impose high costs to the healthcare system and society, but also create space for new and improved patient experiences from embeds and vertical solutions.
• Unlocking patient data and biomarkers for personalized care. Devices can be a powerful patient anchor that can increase defensibility and data moats. This data capture can unlock highly personalized care that is proactive for potential triggers and can guide the triage of acute events.
• Enabling the measurement infrastructure for value-based care (VBC). We are confident that next-gen chronic care needs robust reporting and measurement infrastructures that capture and analyze outcomes effectively. Of course, VBC adoption hinges on various factors, stakeholders, and differs between specialties. That said, we believe that building solutions with outcome-driven insights at the foundation is a needed innovation that also has potential to unlock new systems of record and enable the VBC shift as a result.

We are proud investors in several companies in the chronic care space. Nimbus Health is building the future of tech-enabled pulmonology and we believe their moat is in owning the full delivery stack as well as enabling one of the most interesting data sets in the field.  Recora Health is a leader in virtual cardiac care. Their flagship Virtual Cardiac Rehabilitation Program is the ultimate embed for systems and providers.

Colla Health is a robust and seamless behavioral health embed for oncology practices via the evidence-based Collaborative Care Model (CoCM). They’re filling a key gap in chronic disease journeys. Psyrin is pioneering the next-gen vertical stack for AI-enabled psychiatry, leveraging their patent-pending voice biomarker technology. Impilo is the logistics and data API infrastructure for remote patient monitoring, which plays a crucial role in this evolving landscape.

We also recognize that addressing chronic care management fully will require a range of specific solutions to meet the full scope of patient needs.

Business Model Opportunities in Chronic Care

1) B2B embedded opportunities: We are excited about B2B models that seamlessly integrate core care management fully embedded into health systems or practices.

Health systems already attract patients locally, but they're understaffed and can lack the full suite of specialists needed to serve their population. And at the same time, there is a tailwind of doctors enjoying the benefits reaped by practicing telemedicine.

There is a massive advantage in augmenting existing care delivery at systems and practices with remote patient care, which can enable parts of the care journey to be administered remotely and therefore faster, while testing or other in-person required steps can continue to be served locally.

2) Fully vertically integrated: Companies that own the entire care continuum -from initial engagement to care delivery- have the ultimate moat. While this model introduces operational, logistical, and regulatory complexity, it also grants massive advantages like control to automate workflows, align incentives, ensure consistency and quality.

We believe in the potential of meeting patients where they are and providing the full suite of services, directly.

We're open to startups building in either model.

Are you or someone you know working in this area? We want to speak to you! Send your materials to 2048.vc/pitch-us and let’s build the future of chronic care together.